US 11,833,255 B2
Nanoparticles with pH triggered drug release
Sunandini Chopra, Cambridge, MA (US); Rohit Karnik, Cambridge, MA (US); Amy Wang, Cambridge, MA (US); Omid C. Farokhzad, Waban, MA (US); and Xue-Qing Zhang, Livingston, NJ (US)
Assigned to The Brigham and Women's Hospital, Inc., Boston, MA (US); and Massachusetts Institute Of Technology, Cambridge, MA (US)
Appl. No. 15/766,706
Filed by The Brigham and Women's Hospital, Inc., Boston, MA (US); and MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US)
PCT Filed Oct. 7, 2016, PCT No. PCT/US2016/056193
§ 371(c)(1), (2) Date Apr. 6, 2018,
PCT Pub. No. WO2017/062920, PCT Pub. Date Apr. 13, 2017.
Claims priority of provisional application 62/238,239, filed on Oct. 7, 2015.
Prior Publication US 2018/0318230 A1, Nov. 8, 2018
Int. Cl. A61K 9/51 (2006.01); A61K 9/00 (2006.01); A61K 47/69 (2017.01); A61K 47/68 (2017.01); A61P 3/10 (2006.01); A61P 35/00 (2006.01); A61K 38/28 (2006.01)
CPC A61K 9/5153 (2013.01) [A61K 9/0019 (2013.01); A61K 9/5138 (2013.01); A61K 9/5146 (2013.01); A61K 38/28 (2013.01); A61K 47/6803 (2017.08); A61K 47/6933 (2017.08); A61K 47/6937 (2017.08); A61P 3/10 (2018.01); A61P 35/00 (2018.01); Y02A 50/30 (2018.01)] 16 Claims
 
1. A nanoparticle comprising a pH-responsive polymer blended with a pH-insensitive polymer forming a mixture of the polymers, and a payload molecule, wherein the ratio of the amount of the pH-responsive polymer to the amount of pH-insensitive polymer is in the range from 10:90 to 20:80 by weight.