US 11,833,254 B2
Discoidal nano universal platform for efficient delivery of PNAs
Raman Bahal, Glastonbury, CT (US); Mu-Ping Nieh, Mansfield, CT (US); Armin Tahmasbi Rad, Manchester, CT (US); and Shipra Malik, Storrs, CT (US)
Assigned to UNIVERSITY OF CONNECTICUT, Farmington, CT (US)
Filed by University of Connecticut, Farmington, CT (US)
Filed on May 27, 2021, as Appl. No. 17/332,258.
Claims priority of provisional application 63/030,352, filed on May 27, 2020.
Prior Publication US 2021/0369632 A1, Dec. 2, 2021
Int. Cl. A61K 9/127 (2006.01); A61K 9/51 (2006.01); A61K 47/24 (2006.01); A61K 47/34 (2017.01); A61K 47/26 (2006.01); A61K 47/42 (2017.01); A61K 9/14 (2006.01)
CPC A61K 9/5123 (2013.01) [A61K 9/1271 (2013.01); A61K 9/1274 (2013.01); A61K 9/146 (2013.01); A61K 9/5146 (2013.01); A61K 9/5192 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/34 (2013.01); A61K 47/42 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A self-assembled discoidal PNA delivery vehicle, comprising
a zwitterionic short chain 6:0 dihexanoyl phosphatidylcholine (DHPC);
a zwitterionic long chain 16:0 zwitterionic dipalmitoyl phosphatidylcholine (DPPC);
a charged long chain 16:0 zwitterionic dipalmitoyl phosphatidylglycerol (DPPG);
a polyethylene glycol (PEG2000)-conjugated distearoyl phosphoethanolamine (DSPE-PEG2000),
wherein the DPPC:DHPC:DPPG:DSPE-PEG2000 molar ratio is 69.58:25.1:3.76:2.0; and
an encapsulated PNA molecule.