CPC A61K 9/5123 (2013.01) [A61K 9/1271 (2013.01); A61K 9/1274 (2013.01); A61K 9/146 (2013.01); A61K 9/5146 (2013.01); A61K 9/5192 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/34 (2013.01); A61K 47/42 (2013.01)] | 14 Claims |
1. A self-assembled discoidal PNA delivery vehicle, comprising
a zwitterionic short chain 6:0 dihexanoyl phosphatidylcholine (DHPC);
a zwitterionic long chain 16:0 zwitterionic dipalmitoyl phosphatidylcholine (DPPC);
a charged long chain 16:0 zwitterionic dipalmitoyl phosphatidylglycerol (DPPG);
a polyethylene glycol (PEG2000)-conjugated distearoyl phosphoethanolamine (DSPE-PEG2000),
wherein the DPPC:DHPC:DPPG:DSPE-PEG2000 molar ratio is 69.58:25.1:3.76:2.0; and
an encapsulated PNA molecule.
|