CPC A61K 47/6803 (2017.08) [A61K 39/39558 (2013.01); A61K 47/6849 (2017.08); A61K 49/00 (2013.01); A61K 51/103 (2013.01); A61K 51/1093 (2013.01); A61P 35/02 (2018.01); C07K 16/2803 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01)] | 17 Claims |
1. A method of treating a cKIT positive cancer in a patient in need thereof, comprising administering to said patient an antibody drug conjugate of the formula
Ab-(L-(D)m)n
or a pharmaceutically acceptable salt thereof; wherein
Ab is an antibody or antigen binding fragment thereof that specifically binds to an epitope of human cKIT, wherein said antibody or antigen binding fragment thereof comprises:
(i) a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO: 76, (b) a HCDR2 of SEQ ID NO: 77, (c) a HCDR3 of SEQ ID NO: 78; and a light chain variable region that comprises: (d) a LCDR1 of SEQ ID NO: 85, (e) a LCDR2 of SEQ ID NO: 86, and (f) a LCDR3 of SEQ ID NO: 87; wherein the CDRs of (a)-(f) are defined in accordance with the Kabat definition; or
(ii) a heavy chain variable region that comprises (a) a HCDR1 of SEQ ID NO: 79, (b) a HCDR2 of SEQ ID NO: 80, (c) a HCDR3 of SEQ ID NO: 81; and a light chain variable region that comprises: (d) a LCDR1 of SEQ ID NO: 88, (e) a LCDR2 of SEQ ID NO: 89, and (f) a LCDR3 of SEQ ID NO: 90; wherein the CDRs of (a)-(f) are defined in accordance with the Chothia definition;
L is a linker;
D is a drug moiety;
m is an integer from 1 to 8; and
n is an integer from 1 to 10.
|