US 11,833,175 B2
Red blood cell products and the storage of red blood cells in containers free of phthalate plasticizer
Katherine Radwanski, Highland Park, IL (US); Craig L. Sandford, Buffalo Grove, IL (US); Kyungyoon Min, Kildeer, IL (US); Bryan Blickhan, Libertyville, IL (US); Daniel Lynn, Spring Grove, IL (US); and Tat Mui, Chicago, IL (US)
Assigned to Fenwal, Inc., Lake Zurich, IL (US)
Filed by Fenwal, Inc., Lake Zurich, IL (US)
Filed on Apr. 23, 2021, as Appl. No. 17/238,804.
Application 17/238,804 is a division of application No. 15/974,914, filed on May 9, 2018, granted, now 11,000,551.
Application 15/974,914 is a division of application No. 14/122,847, granted, now 9,993,389, issued on Jun. 12, 2018, previously published as PCT/US2012/056100, filed on Sep. 19, 2012.
Claims priority of provisional application 61/595,891, filed on Feb. 7, 2012.
Claims priority of provisional application 61/566,409, filed on Dec. 2, 2011.
Claims priority of provisional application 61/549,562, filed on Oct. 20, 2011.
Claims priority of provisional application 61/536,370, filed on Sep. 19, 2011.
Prior Publication US 2021/0236555 A1, Aug. 5, 2021
Int. Cl. A61K 35/18 (2015.01); A61K 45/06 (2006.01); A01N 1/02 (2006.01); A61J 1/10 (2006.01); B32B 27/08 (2006.01); B32B 27/30 (2006.01); B32B 27/32 (2006.01); A61J 1/14 (2023.01); A61J 1/00 (2023.01)
CPC A61K 35/18 (2013.01) [A01N 1/0226 (2013.01); A01N 1/0263 (2013.01); A01N 1/0273 (2013.01); A61J 1/00 (2013.01); A61J 1/1468 (2015.05); A61K 45/06 (2013.01); B32B 27/08 (2013.01); B32B 27/304 (2013.01); B32B 27/32 (2013.01); B32B 2270/00 (2013.01); B32B 2307/7244 (2013.01); B32B 2439/80 (2013.01)] 8 Claims
 
1. A method for providing a transfusible red blood cell product substantially free of phthalate plasticizer comprising:
(a) deriving red blood cell concentrate from whole blood;
(b) combining said concentrated red blood cells with a hypotonic solution; and
(c) storing said combination of concentrated red blood cells and a hypotonic additive solution in a container that includes a polymeric material that is substantially free of phthalate and including a first extractable plasticizer comprising 1, 2-cyclohexane dicarboxylic acid diisononyl ester and a second extractable plasticizer comprising a citrate ester.