CPC A61K 31/727 (2013.01) [A61K 9/0019 (2013.01); A61P 7/02 (2018.01)] | 10 Claims |
1. An oligosaccharide compound or a pharmaceutically acceptable salt thereof, characterized in that, the oligosaccharide compound has antithrombotic activity, and has a general structure represented by Formula (I):
in the formula,
n is a number from 0 to 8;
R1, R2, R3, R4, and R5 are independently selected from —H or —SO3H;
R6 is selected from —H, a substituted or unsubstituted C1-C6 hydrocarbon group or a C7-C12 aryl group;
R7 is selected from —H, —SO3H, C2-C5 acyl;
R8 is Formula (II), Formula (III) or Formula (IV):
in Formula(II), Formula (III) and Formula(IV),
R1, R2, R3, R4, R5, R6 and R7 are defined as above;
R9 and R10 are independently selected from —H, a substituted or unsubstituted C1-C6 hydrocarbon group or a C7-C12 aryl group; and
R11 is selected from —NHR12, —OR13, wherein R12 and R13 are independently selected from —H, a substituted or unsubstituted C1-C6 hydrocarbon group, or a C7-C12 aryl group;
wherein, the compound is a purified oligosaccharide compound prepared by β-elimination depolymerization and terminal reduction with a reducing agent during the β-elimination or β-elimination depolymerization and a peeling reaction with a strong base during the β-elimination, followed by isolation and purification.
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