US 11,833,159 B2
Non-hormonal steroid modulators of NF-kB for treatment of disease
John M. McCall, Boca Grande, FL (US); Eric Hoffman, Rockville, MD (US); and Kanneboyina Nagaraju, Highland, MD (US)
Assigned to ReveraGen BioPharma, Inc., Rockville, MD (US)
Filed by ReveraGen BioPharma, Inc., Rockville, MD (US)
Filed on Oct. 28, 2020, as Appl. No. 17/082,521.
Application 15/483,863 is a division of application No. 15/229,947, filed on Aug. 5, 2016, granted, now 9,649,320, issued on May 16, 2017.
Application 14/164,779 is a division of application No. 13/678,253, filed on Nov. 15, 2012, granted, now 8,673,887, issued on Mar. 18, 2014.
Application 13/678,253 is a division of application No. 13/327,628, filed on Dec. 15, 2011, granted, now 8,334,279, issued on Dec. 18, 2012.
Application 13/327,628 is a division of application No. 12/473,921, filed on May 28, 2009, granted, now 8,207,151, issued on Jun. 26, 2012.
Application 17/082,521 is a continuation of application No. 16/226,061, filed on Dec. 19, 2018, granted, now 10,857,161.
Application 16/226,061 is a continuation of application No. 15/483,863, filed on Apr. 10, 2017, granted, now 10,206,933, issued on Feb. 19, 2019.
Application 15/229,947 is a continuation of application No. 14/164,779, filed on Jan. 27, 2014, granted, now 9,434,758, issued on Sep. 6, 2016.
Claims priority of provisional application 61/056,715, filed on May 28, 2008.
Prior Publication US 2021/0052606 A1, Feb. 25, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/573 (2006.01); A61K 31/575 (2006.01); C07J 5/00 (2006.01); A61K 31/57 (2006.01); A61P 1/04 (2006.01); A61P 1/16 (2006.01); A61P 3/00 (2006.01)
CPC A61K 31/573 (2013.01) [A61K 31/57 (2013.01); A61K 31/575 (2013.01); A61P 1/04 (2018.01); A61P 1/16 (2018.01); A61P 3/00 (2018.01); C07J 5/0038 (2013.01); C07J 5/0053 (2013.01); C07J 5/0076 (2013.01); Y02A 50/30 (2018.01)] 12 Claims
 
1. A pharmaceutical composition comprising between 10 to 200 mg of a compound having the structural formula

OG Complex Work Unit Chemistry
or a salt thereof,
wherein the pharmaceutical composition is formulated for oral administration and
wherein the compound is present in an amount effective to treat or reduce the symptoms of muscular dystrophy.