US 11,833,132 B1
Method of synthesis of a nanocomposite including silymarin-loaded collagen nanoparticles
Mai Mostafa Khalaf Ali, Al-Ahsa (SA); Hany Mohamed Abd El-Lateef Ahmed, Al-Ahsa (SA); Ahmed Mohammed Abu-Dief Mohammed, Al-Ahsa (SA); Hazem Mohamed Shaheen, Al-Ahsa (SA); Gaber Elsaber Abd El-Wanis Batiha, Al-Ahsa (SA); Manal Aly Shalaby, Al-Ahsa (SA); and Amany Mabrouk Abd Elhady Alamh, Al-Ahsa (SA)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Jun. 26, 2023, as Appl. No. 18/214,021.
Int. Cl. A61K 31/357 (2006.01); A61K 9/51 (2006.01); A61K 9/50 (2006.01)
CPC A61K 31/357 (2013.01) [A61K 9/5089 (2013.01); A61K 9/5123 (2013.01); A61K 9/5169 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A method of synthesizing a nanocomposite including silymarin-loaded collagen nanoparticles, comprising:
dissolving silymarin in a first alcohol to provide a solution;
mixing the solution with acetic acid to provide an acetic acid mixture;
adding glutaraldehyde to the mixture to provide silymarin nanoparticles;
adding the silymarin nanoparticles to a second alcohol to provide a silymarin nanoparticle mixture;
adding collagen nanoparticles to the silymarin nanoparticle mixture to provide a silymarin/collagen nanoparticle mixture;
adding glutaraldehyde to the silymarin/collagen mixture to provide the nanocomposite formulation.