US 11,833,131 B2
Compositions and methods for treating inflammatory diseases
Hinanit Koltai, Rishon-LeZion (IL); Yoram Kapulnik, Karmey Yosef (IL); Moran Mazuz, Rishon-LeZion (IL); and Timna Naftali, Tel-Aviv (IL)
Assigned to The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research, Rishon-LeZion (IL); and Mor Research Applications Ltd., Ramat Gan (IL)
Appl. No. 16/491,197
Filed by The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Rishion-LeZion (IL); and Mor Research Applications Ltd., Tel-Aviv (IL)
PCT Filed Mar. 5, 2018, PCT No. PCT/IL2018/050248
§ 371(c)(1), (2) Date Sep. 5, 2019,
PCT Pub. No. WO2018/163163, PCT Pub. Date Sep. 13, 2018.
Claims priority of provisional application 62/537,050, filed on Jul. 26, 2017.
Claims priority of provisional application 62/467,157, filed on Mar. 5, 2017.
Prior Publication US 2020/0222359 A1, Jul. 16, 2020
Int. Cl. A61K 31/353 (2006.01); A61K 31/01 (2006.01); A61K 31/015 (2006.01); A61K 31/045 (2006.01); A61K 31/05 (2006.01); A61K 31/12 (2006.01); A61K 31/194 (2006.01); A61P 1/00 (2006.01); A61P 29/00 (2006.01); A61K 31/352 (2006.01); A61K 36/185 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/353 (2013.01) [A61K 31/01 (2013.01); A61K 31/015 (2013.01); A61K 31/045 (2013.01); A61K 31/05 (2013.01); A61K 31/12 (2013.01); A61K 31/194 (2013.01); A61K 31/352 (2013.01); A61K 36/185 (2013.01); A61P 1/00 (2018.01); A61P 29/00 (2018.01); A61K 45/06 (2013.01)] 10 Claims
 
1. A method of treating an inflammatory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a liquid chromatography fraction of a cannabis extract containing components
 
 
 
 Compounds %
 
 
 
 
 D-Limonene 0.097
 
 Glycerol 0.086
 
 β-Caryophyllene 0.103
 
 Humulene 0.03
 
 malic acid 0.035
 
 α-Farnesene 0.034
 
 myristic acid 0.023
 
 palmitic acid ME 0.014
 
 palmitic acid 0.514
 
 alkane 0.015
 
 Linolenic acid 0.074
 
 Linoleic acid 0.388
 
 stearic acid 3.135
 
 Arachidonic acid 0.022
 
 CBD 0.036
 
 Cholesterol 0.499
 
 THC 1.724
 
 THCA 83.172
 
 CBG 1.399
 
 CBN 3.537
 
 b-sitosterol 1.697
 
 stigmasterol 1.468
 
 silyl 1.184
 
 alkane 0.714,
 
 
thereby treating the inflammatory disease in the subject.