CPC C07K 16/32 (2013.01) [C07K 16/2863 (2013.01); C07K 16/30 (2013.01); C07K 16/46 (2013.01); A61K 38/00 (2013.01); C07K 2317/31 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/64 (2013.01); C07K 2317/92 (2013.01)] | 14 Claims |
1. An isolated bi-specific antigen-binding polypeptide comprising an antibody heavy chain comprising a first VH domain that specifically binds to human HER2, wherein the heavy chain is C-terminally linked to a second VH domain that specifically binds to human PDGFRβ, wherein the polypeptide is devoid of antibody light chains, and wherein the VH domain that binds specifically to human HER2 comprises:
a HCDR3 comprising the amino acid sequence set forth as SEQ ID NO: 1,
a HCDR2 comprising the amino acid sequence set forth as SEQ ID NO: 2, and
a HCDR1 comprising the amino acid sequence set forth as SEQ ID NO: 3; or
a HCDR3 comprising the amino acid sequence set forth in SEQ ID NO: 4,
a HCDR2 comprising the amino acid sequence set forth in SEQ ID NO: 5, and
a HCDR1 comprising the amino acid sequence set forth in SEQ ID NO: 6; or
a HCDR3 comprising the amino acid sequence set forth in SEQ ID NO: 7,
a HCDR2 comprising the amino acid sequence set forth in SEQ ID NO: 8, and
a HCDR1 comprising the amino acid sequence set forth in SEQ ID NO: 9; or
a HCDR3 comprising the amino acid sequence set forth in SEQ ID NO: 10,
a HCDR2 comprising the amino acid sequence set forth in SEQ ID NO: 11, and
a HCDR1 comprising the amino acid sequence set forth in SEQ ID NO: 12.
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