CPC C07K 14/315 (2013.01) [A61K 39/092 (2013.01); A61P 31/04 (2018.01); A61K 2039/552 (2013.01); A61K 2039/55505 (2013.01); C07K 2319/00 (2013.01)] | 21 Claims |
1. A method for immunizing a mammalian subject against a Streptococcus suis infection, comprising administering to said mammalian subject an immunologically effective amount of an immunogenic composition comprising a fusion protein comprising
a) a first immunogenic polypeptide unit, and
b) a second immunogenic polypeptide unit,
wherein said first and second immunogenic polypeptide units are immunogenic polypeptide fragments selected from the group consisting of:
amino acid sequences of at least 100 amino acids in length with at least 80% identity to fragments of SEQ ID NO:4,
amino acid sequences of at least 100 amino acids in length with at least 80% identity to fragments of SEQ ID NO:3,
amino acid sequences of at least 100 amino acids in length with at least 80% identity to fragments of SEQ ID NO:2,
an amino acid sequence with at least 80% identity to a fragment comprising SEQ ID NO:5, provided the fragment comprising the amino acid sequences with at least 80% identity to SEQ ID NO:5 is 100-500 amino acids long; and
an amino acid sequence with at least 80% identity to a fragment comprising SEQ ID NO:6, provided the fragment comprising the amino acid sequences with at least 80% identity to SEQ ID NO:6 is 100-500 amino acids long.
|