US 11,814,415 B2
Vaccine against S. suis infection
Bengt Guss, Uppsala (SE); Lars Frykberg, Storvreta (SE); Margareta Flock, Bromma (SE); Jan-Ingmar Flock, Bromma (SE); and Karl Olov Zachrisson, Spånga (SE)
Assigned to INTERVACC AB, Hägersten (SE)
Filed by INTERVACC AB, Hägersten (SE)
Filed on Oct. 22, 2021, as Appl. No. 17/508,791.
Application 17/508,791 is a continuation of application No. 15/735,548, granted, now 11,155,585, previously published as PCT/EP2016/066311, filed on Jul. 8, 2016.
Claims priority of application No. 15176063 (EP), filed on Jul. 9, 2015.
Prior Publication US 2022/0048957 A1, Feb. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/315 (2006.01); A61K 39/09 (2006.01); A61P 31/04 (2006.01); A61K 39/00 (2006.01)
CPC C07K 14/315 (2013.01) [A61K 39/092 (2013.01); A61P 31/04 (2018.01); A61K 2039/552 (2013.01); A61K 2039/55505 (2013.01); C07K 2319/00 (2013.01)] 21 Claims
 
1. A method for immunizing a mammalian subject against a Streptococcus suis infection, comprising administering to said mammalian subject an immunologically effective amount of an immunogenic composition comprising a fusion protein comprising
a) a first immunogenic polypeptide unit, and
b) a second immunogenic polypeptide unit,
wherein said first and second immunogenic polypeptide units are immunogenic polypeptide fragments selected from the group consisting of:
amino acid sequences of at least 100 amino acids in length with at least 80% identity to fragments of SEQ ID NO:4,
amino acid sequences of at least 100 amino acids in length with at least 80% identity to fragments of SEQ ID NO:3,
amino acid sequences of at least 100 amino acids in length with at least 80% identity to fragments of SEQ ID NO:2,
an amino acid sequence with at least 80% identity to a fragment comprising SEQ ID NO:5, provided the fragment comprising the amino acid sequences with at least 80% identity to SEQ ID NO:5 is 100-500 amino acids long; and
an amino acid sequence with at least 80% identity to a fragment comprising SEQ ID NO:6, provided the fragment comprising the amino acid sequences with at least 80% identity to SEQ ID NO:6 is 100-500 amino acids long.