	US 11,814,397 B2
	Methods for crystallization of drugs
Hongxia Zeng, Maple Grove, MN (US); Jonathan Pascal Chaky, Saint Paul, MN (US); and Yen-Lane Chen, New Brighton, MN (US)
Assigned to Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed by BOSTON SCIENTIFIC SCIMED, INC., Maple Grove, MN (US)
Filed on Mar. 12, 2021, as Appl. No. 17/200,434.
Claims priority of provisional application 63/000,861, filed on Mar. 27, 2020.
Prior Publication US 2021/0300938 A1, Sep. 30, 2021
Int. Cl. C07D 493/16 (2006.01)

CPC C07D 493/16 (2013.01) [C07B 2200/13 (2013.01)]

16 Claims

1. A method for crystallizing a drug, the method comprising:

combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension;

wherein the nucleation initiator includes microcrystals characterized by a flat sheet morphology; and

incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.