CPC C07D 215/14 (2013.01) [B01J 23/30 (2013.01); B01J 27/232 (2013.01); B01J 27/24 (2013.01); B01J 31/121 (2013.01); B01J 31/122 (2013.01); B01J 31/128 (2013.01); B01J 2531/11 (2013.01); B01J 2531/12 (2013.01)] | 28 Claims |
1. A method for synthesizing pitavastatin t-butyl ester, comprising the steps of:
(a) obtaining a substance B through reacting (4R-CIS)-6-chloromethyl-2,2-dimethyl-1,3-dioxolane-4-acetic acid tert-butyl ester with a substance A under an action of a first base catalyst;
(b) oxidizing with an oxidizing agent to obtain a substance C;
(c) reacting with 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-formaldehyde under an action of a second base catalyst to obtain a substance D; and
(d) carrying out an acid deprotection to obtain pitavastatin t-butyl ester, wherein a structural formula of said substance A, said substance B, said substance C, said substance D, and said pitavastatin t-butyl ester is as follows:
R is one of hydrogen, alkyl, cycloalkyl, phenyl, and substituted phenyl.
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