CPC A61K 51/0497 (2013.01) [A61P 35/00 (2018.01)] | 31 Claims |
1. A compound of formula (I):
wherein:
Z is tetrazole or CO2Q;
Q is H or a protecting group;
m is an integer selected from the group consisting of 1, 2, 3, 4, and 5;
R is —CH2—R1; wherein R1 is:
wherein X1 is —CR3 or N, wherein R3 is H or C1-C4 alkyl;
wherein X is selected from the group consisting of a radioisotope of iodine, a radioisotope of bromine, and a radioisotope of astatine;
L is a linker selected from the group consisting of C1, C2, C3, C4, C5, and C6 alkylene, C3, C4, C5, and C6 cycloalkylene, and arylene, each of which can be substituted or unsubstituted;
W is selected from the group consisting of —NR2—(C═O)—, —NR2—(C═S)—, —(C═O)—NR2—, and —(C═S)—NR2—; wherein each occurrence of L and W can be the same or different;
R2 is H or C1-C4 alkyl;
n is an integer selected from the group consisting of 1, 2, and 3;
Ch is a chelating agent that can comprise a metal; and
pharmaceutically acceptable salts thereof.
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