CPC A61K 35/17 (2013.01) [A61K 38/1774 (2013.01)] | 3 Claims |
1. A method for reducing the number of myeloid-derived suppressor cells (MDSC), tumor associated macrophages (TAM), or both, in a subject in need thereof, the method comprising:
administering to the subject, intravenously or by injection, a therapeutically effective amount of a genetically modified cell comprising a chimeric antigen receptor (CAR) that specifically binds CD33, wherein the CAR comprises an amino acid sequence having at least 95% sequence identity to SEQ ID NO: 16, and
wherein the genetically modified cell is a T cell or NK-92 cell.
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