CPC A61K 31/506 (2013.01) [A61K 31/496 (2013.01); A61P 21/06 (2018.01)] | 21 Claims |
1. A method for increasing muscle strength, comprising contacting a skeletal or smooth muscle of a subject in need thereof with a pharmacological agent comprising an F-actin disrupting agent at a dosage between about 0.01 to about 20 mg per kg of the subject applied for less than or equal to 5 hours to transiently depolymerize actin thereby reducing mechanical stiffness of a muscle tissue, wherein the F-actin disrupting agent comprises an actin nuclease inhibitor or tropomyosin inhibitor.
|