	US 11,813,240 B1
	Method of using microemulsion, and method of treating fungal infection
George A. Cioe, Narragansett, RI (US); and Matthew W. Zoeller, Georgetown, SC (US)
Assigned to THE TETRA CORPORATION, Eaton Rapids, MI (US); and George A. Cioe, Narragansett, RI (US)
Filed by The Tetra Corporation, Narragansett, RI (US); and George A. Cioe, Narragansett, RI (US)
Filed on Feb. 25, 2021, as Appl. No. 17/185,576.
Application 17/185,576 is a continuation of application No. 16/023,824, filed on Jun. 29, 2018, granted, now 10,959,975.
Claims priority of provisional application 62/618,289, filed on Jan. 17, 2018.
Claims priority of provisional application 62/580,689, filed on Nov. 2, 2017.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/06 (2006.01); A61K 8/04 (2006.01); A61K 8/06 (2006.01); A61K 9/10 (2006.01); A61K 9/107 (2006.01); A61Q 19/00 (2006.01); A61K 31/27 (2006.01); A61K 47/10 (2017.01); A61K 47/44 (2017.01); A61K 47/14 (2017.01)

CPC A61K 31/27 (2013.01) [A61K 9/1075 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/44 (2013.01)]

20 Claims

1. A method of using a microemulsion, the method comprising:

applying the microemulsion to a site of treatment of a human or animal, the microemulsion comprising

one or more of Oleth-5, Oleth-10, and Oleth-3 Phosphate,

an aqueous continuous phase comprising:

water;

one or more of butylene glycol, propylene glycol, glycerin, xylitol, ethylhexylglycerin, caprylyl glycol, sorbitol, phenoxyethanol, aminomethylpropanol, aminomethylpropanediol, and ethoxydiglycol;

N-acetyl-1-cysteine; and

urea;

a dispersed phase comprising:

a vehicle comprising Simmondsia Chinensis Oil and C12-15 alkyl benzoate; and

tolnaftate dissolved in the vehicle, the antifungal microemulsion comprising 0.5 to 2.0 w/w % of tolnaftate.