CPC A61B 90/39 (2016.02) [A61B 8/0841 (2013.01); A61B 8/12 (2013.01); A61B 8/14 (2013.01); A61B 8/481 (2013.01); A61K 31/729 (2013.01); A61K 49/223 (2013.01); A61K 51/048 (2013.01); A61B 2090/3929 (2016.02); A61B 2562/0204 (2013.01); A61B 2562/12 (2013.01)] | 20 Claims |
1. An ultrasound activated marker, comprising:
a layer of polymeric matrix; and
hollow shells at least partially embedded in the layer of polymeric matrix, and positioned close to a top surface of the layer of polymeric matrix, wherein each of the hollow shells is configured to retain air in a hollow core and provide an ultrasound contrast agent for ultrasound imaging, and
wherein the hollow shells are silica hollow shells that are provided from polystyrene beads with an organic compound that includes diethylenetriamine (DETA) in a base solution including ethanol, and
wherein surfaces of the polystyrene beads are modified by the DETA that is adsorbed onto the surfaces of the polystyrene beads.
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