US 11,808,763 B2
Method and apparatus for ordered nanoplasmonic sensor formation through microfluidic assembly
Amogha Tadimety, West Lebanon, NH (US); and John X. J. Zhang, Hanover, NH (US)
Assigned to THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Appl. No. 16/492,128
Filed by THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
PCT Filed Mar. 7, 2018, PCT No. PCT/US2018/021392
§ 371(c)(1), (2) Date Sep. 7, 2019,
PCT Pub. No. WO2018/165331, PCT Pub. Date Sep. 13, 2018.
Claims priority of provisional application 62/468,499, filed on Mar. 8, 2017.
Prior Publication US 2021/0132054 A1, May 6, 2021
Int. Cl. G01N 33/543 (2006.01); G01N 21/552 (2014.01); G01N 33/553 (2006.01); B82Y 15/00 (2011.01); B82Y 30/00 (2011.01)
CPC G01N 33/54373 (2013.01) [G01N 21/554 (2013.01); G01N 33/54346 (2013.01); G01N 33/553 (2013.01); B82Y 15/00 (2013.01); B82Y 30/00 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A plasmon-resonance biosensor comprising:
a plurality of precious metal nanorods, the precious metal nanorods having a long dimension greater than a narrow dimension by a factor of at least 1.5 and a maximum dimension less than one half micron;
the nanorods organized in rows;
the nanorods in the rows are oriented with the long dimension approximately parallel to the rows;
the precious metal nanorods are conjugated with a biological probe material capable of binding to an analyte, the biological probe material, is a protein-nucleic acid (PNA) or a complimentary DNA.