US 11,808,758 B2
Sample carrier for optical measurements
Joseph Joel Pollak, Neve Daniel (IL); Sarah Levy Schreier, Jaffa (IL); Yochay Shlomo Eshel, Sde Warburg (IL); Amir Zait, Binyamina (IL); Sharon Pecker, Rehovot (IL); and Trevor Ruggiero, Somerville, MA (US)
Assigned to S.D. Sight Diagnostics Ltd., Tel Aviv (IL)
Filed by S.D. SIGHT DIAGNOSTICS LTD., Tel Aviv (IL)
Filed on Oct. 28, 2020, as Appl. No. 17/082,483.
Application 17/082,483 is a continuation of application No. 16/098,893, granted, now 11,307,196, previously published as PCT/IL2017/050523, filed on May 11, 2017.
Claims priority of provisional application 62/334,521, filed on May 11, 2016.
Prior Publication US 2021/0072226 A1, Mar. 11, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/50 (2006.01); G01N 21/31 (2006.01); G01N 21/59 (2006.01); G01N 21/64 (2006.01); G01N 21/03 (2006.01)
CPC G01N 33/50 (2013.01) [G01N 21/0303 (2013.01); G01N 21/31 (2013.01); G01N 21/59 (2013.01); G01N 21/64 (2013.01); G01N 2201/0662 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method for determining a property of a biological sample, the method comprising:
placing the sample into a sample carrier that comprises a plurality of regions, the plurality of regions:
having upper and lower surfaces,
having respective heights between the upper and lower surfaces that are different from each other, and
being configured such that cells within the biological sample form a monolayer of cells on the lower surface within the plurality of regions of the sample carrier,
the monolayer within respective regions of the sample carrier having respective, different densities from each other, due to the respective regions of the sample carrier having respective heights that are different from each other;
acquiring microscopic images of each of the plurality of regions; and
using a computer processor:
performing measurements upon cell types that have a relatively high density upon microscopic images of the monolayer within a region of the sample chamber having a relatively low height; and
performing measurements upon cell types that have a relatively low density upon microscopic images of the monolayer within a region of the sample chamber having a relatively great height.