US 11,808,750 B2
Solid-phase sampling device and methods for point-source sampling of polar organic analytes
Andrew J. Boggess, Aiken, SC (US); Stephen L. Crump, Martinez, GA (US); and Thomas L. White, Evans, GA (US)
Assigned to Battelle Savannah River Alliance, LLC, Aiken, SC (US)
Filed by SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC, Aiken, SC (US)
Filed on Apr. 29, 2021, as Appl. No. 17/244,167.
Application 17/244,167 is a division of application No. 16/170,185, filed on Oct. 25, 2018, granted, now 11,022,593.
Prior Publication US 2021/0263002 A1, Aug. 26, 2021
Int. Cl. G01N 33/18 (2006.01); G01N 1/10 (2006.01); G01N 1/40 (2006.01)
CPC G01N 33/1826 (2013.01) [G01N 1/10 (2013.01); G01N 1/405 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A sampling device comprising:
a liquid inlet;
a first layer downstream of the liquid inlet, the first layer comprising a first solid phase extraction medium, the first layer further comprising a first derivatizing agent for a first targeted analyte, reaction between the first derivatizing agent and the first targeted analyte forming a first derivatized analyte;
a second layer downstream of the first layer, the second layer comprising a second solid phase extraction medium, the second layer further comprising an isotopically labeled analogue of the first derivatized analyte; and
a liquid outlet downstream of the second layer.