CPC C12Q 1/6876 (2013.01) [A61K 31/155 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01)] | 12 Claims |
1. A method for identifying a patient suffering from diabetes who will benefit from metformin treatment, said method comprising:
(a) administering metformin to a patient having diabetes;
(b) obtaining a sample from the patient;
(c) determining the level of GDF15 or a functional variant thereof in the sample; and
(d) comparing the level of GDF15 or functional variant thereof after the administration in step (a) to the level of GDF15 or functional variant in the patient before the administration or to a reference value, wherein an increased level of GDF15 or functional variant thereof after the administration in step (a) indicates that the patient responds to the metformin administration,
wherein the functional variant of GDF15 comprises a sequence having at least 80% sequence identity to SEQ ID NO: 1.
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