CPC C12N 9/96 (2013.01) [A61K 47/59 (2017.08); A61K 47/60 (2017.08); C08G 83/008 (2013.01); C12N 9/6424 (2013.01); C12N 9/6427 (2013.01); C12Y 304/21001 (2013.01); C12Y 304/21004 (2013.01); C12Y 304/21062 (2013.01); C12Y 304/21064 (2013.01); B82Y 5/00 (2013.01)] | 7 Claims |
1. A monodisperse protein-dendron conjugate of Formula I:
wherein:
hydrophilic protein (A) is selected from the group consisting of serine proteases, cysteine proteases, aspartic proteases, metalloproteases, fusion proteins composed of a serine protease and another functional protein, an antibody, and a peptide;
a hydrophobic benzyl ether dendrimer Gn (C) is a dendrimer having formula G2, G3, or G4 represented by:
n is 1 to 30;
wherein molecular weight of macromolecular amphiphilic activity-based probe (MAABP) is in a range of 2-8 kDa consisting of a fluorophosphonate of a monodisperse oligoethylene glycol as a hydrophilic spacer (B) and the hydrophobic benzyl ether dendrimer Gn (C).
|