CPC C12N 9/6424 (2013.01) [A61K 31/397 (2013.01); A61K 45/06 (2013.01); C07K 14/435 (2013.01); C12Y 304/21109 (2013.01); A61K 38/00 (2013.01)] | 56 Claims |
1. A modified membrane type serine protease (MTSP-1) polypeptide, comprising:
an amino acid sequence having at least 80% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 2, wherein said amino acid sequence comprises, with reference to numbering in SEQ ID NO:1, the following modifications:
Q637H, I640S, D661T, F664S, Y666W, D705K, F706G, InsV, T707P, F708L, G759H, Q783L and Q802D (equivalent to Q38H, I41S, D60bT, F60eS, Y60gW, D96K, F97G, Ins97aV, T98P, F99L, G151H, Q175L, and Q192D, respectively, by chymotrypsin numbering); and wherein modifications comprise insertions, deletions and/or replacements in the unmodified MTSP-1 polypeptide.
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