US 11,807,852 B2
Compositions and methods for reactivating latent immunodeficiency virus
Melanie Ott, Mill Valley, CA (US); and Daniela Boehm, San Francisco, CA (US)
Assigned to The J. David Gladstone Institutes, San Francisco, CA (US)
Filed by The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone, San Francisco, CA (US)
Filed on Jul. 20, 2021, as Appl. No. 17/380,773.
Application 16/422,753 is a division of application No. 15/488,212, filed on Apr. 14, 2017, granted, now 10,351,853.
Application 17/380,773 is a continuation of application No. 16/422,753, filed on May 24, 2019, granted, now 11,098,309.
Application 15/488,212 is a continuation in part of application No. PCT/US2015/055377, filed on Oct. 13, 2015.
Claims priority of provisional application 62/063,822, filed on Oct. 14, 2014.
Prior Publication US 2022/0090085 A1, Mar. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/113 (2010.01); A61K 38/15 (2006.01); A61K 45/06 (2006.01); A61K 31/19 (2006.01); A61K 31/22 (2006.01); A61K 31/365 (2006.01); A61K 31/551 (2006.01); A61K 31/713 (2006.01); A61K 31/235 (2006.01); A61K 31/496 (2006.01); A61K 31/538 (2006.01); A61K 31/167 (2006.01); A61K 31/222 (2006.01)
CPC C12N 15/1137 (2013.01) [A61K 31/167 (2013.01); A61K 31/19 (2013.01); A61K 31/22 (2013.01); A61K 31/222 (2013.01); A61K 31/235 (2013.01); A61K 31/365 (2013.01); A61K 31/496 (2013.01); A61K 31/538 (2013.01); A61K 31/551 (2013.01); A61K 31/713 (2013.01); A61K 38/15 (2013.01); A61K 45/06 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A drug delivery device comprising:
a) a first container comprising a SMYD2 inhibitor that reactivates latent immunodeficiency virus transcription; and
b) a second container comprising an agent that inhibits an immunodeficiency virus function selected from viral replication, viral protease activity, viral reverse transcriptase activity, viral entry into a cell, viral integrase activity, viral Rev activity, viral Tat activity, viral Nef activity, viral Vpr activity, viral Vpu activity, and viral Vif activity.