US 11,807,726 B2
Method of crosslinking glycosaminoglycans
Rachel Auzely-Velty, Grenoble (FR); Tamiris Figueiredo, Saint Martin d'Heres (FR); Laura Jing Jing, Antibes (FR); Craig Steven Harris, Biot (FR); Jean-Guy Boiteau, Opio (FR); Thibaut Gerfaud, Mouans Satoux (FR); and Loic Tomas, Le Biot (FR)
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR)
Filed by Galderma Research & Development, Biot (FR); and Centre National de la Recherche Scientifique, Paris (FR)
Filed on Nov. 24, 2021, as Appl. No. 17/535,314.
Application 17/535,314 is a continuation of application No. 16/322,615, granted, now 11,214,655, previously published as PCT/EP2017/069574, filed on Aug. 2, 2017.
Claims priority of provisional application 62/370,479, filed on Aug. 3, 2016.
Claims priority of application No. 16206624 (EP), filed on Dec. 23, 2016.
Prior Publication US 2022/0081519 A1, Mar. 17, 2022
Int. Cl. C08J 3/075 (2006.01); C08L 5/08 (2006.01); C08K 5/55 (2006.01); C08K 5/1545 (2006.01); C08J 3/24 (2006.01); C08B 37/00 (2006.01); C08B 37/08 (2006.01); A61K 31/728 (2006.01)
CPC C08J 3/075 (2013.01) [A61K 31/728 (2013.01); C08B 37/0063 (2013.01); C08B 37/0072 (2013.01); C08J 3/24 (2013.01); C08K 5/1545 (2013.01); C08K 5/55 (2013.01); C08L 5/08 (2013.01); C08J 2305/08 (2013.01); C08L 2203/02 (2013.01); C08L 2312/00 (2013.01)] 4 Claims
 
1. Crosslinked hyaluronic acids, wherein said crosslinked hyaluronic acids are crosslinked via a phenylboronic acid crosslinker formed between a fructose moiety of a fructose modified hyaluronic acid of formula (HA-fructose):

OG Complex Work Unit Chemistry
and a phenylboronic acid of a second hyaluronic acid grafted with the phenylboronic acid via an amide bond.