US 11,807,677 B2
Microbe-binding molecules and uses thereof
Alexander Watters, North Andover, MA (US); Brendon Dusel, West Roxbury, MA (US); Michael Super, Lexington, MA (US); Mark Cartwright, West Newton, MA (US); and Donald E. Ingber, Boston, MA (US)
Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US)
Filed by PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US)
Filed on Dec. 16, 2021, as Appl. No. 17/552,662.
Application 17/552,662 is a division of application No. 16/879,015, filed on May 20, 2020, granted, now 11,236,149.
Application 16/879,015 is a division of application No. 16/553,635, filed on Aug. 28, 2019, granted, now 10,696,733, issued on Jun. 30, 2020.
Application 16/553,635 is a continuation of application No. 15/750,788, granted, now 10,435,457, issued on Oct. 8, 2019, previously published as PCT/US2016/045509, filed on Aug. 4, 2016.
Claims priority of provisional application 62/201,745, filed on Aug. 6, 2015.
Prior Publication US 2022/0281955 A1, Sep. 8, 2022
Int. Cl. C07K 14/78 (2006.01); G01N 33/569 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/78 (2013.01) [C07K 14/00 (2013.01); C07K 14/4726 (2013.01); C07K 19/00 (2013.01); G01N 33/569 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01); G01N 2333/78 (2013.01); G01N 2400/00 (2013.01)] 20 Claims
 
1. A multimeric molecule comprising:
a) a first microbe-binding molecule comprising:
i) a collagen domain;
ii) an Fc domain of an immunoglobulin; and
iii) a microbe-binding domain comprising a helical domain and a carbohydrate recognition domain (CRD); and
b) a second microbe-binding molecule comprising:
i) a collagen domain;
ii) an Fc domain of an immunoglobulin; and
iii) a microbe-binding domain comprising a helical domain and a carbohydrate recognition domain (CRD).