CPC C07K 14/4705 (2013.01) [A61K 35/39 (2013.01); A61K 38/26 (2013.01); C07K 14/4723 (2013.01); C07K 14/4726 (2013.01); C12N 5/0676 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01); C12N 2501/335 (2013.01); C12N 2501/998 (2013.01)] | 9 Claims |
1. A compound having the formula of (I):
X-L-Y (I)
wherein
X is selected from islet neogenesis-associated protein peptide (INGAP-PP) or an analog thereof, or human proIslet peptide (HIP) or an analog thereof;
L is a linker selected from (EAAAK)m, wherein m is 1, 2 or 3 (SEQ ID NO: 122), A(EAAAK)4ALEA(EAAAK)4A (SEQ ID NO: 124), AEAAAKEAAAKA (SEQ ID NO: 127), PAPAP (SEQ ID NO: 128) and (AP)n, wherein n is an integer selected from 5-17 (SEQ ID NO: 129); and
Y is an epidermal growth factor receptor agonist or a cathelicidin antimicrobial peptide, or an analog thereof.
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