CPC C07K 16/28 (2013.01) [A61K 9/0019 (2013.01); A61K 47/6817 (2017.08); A61P 35/00 (2018.01); C07K 16/2809 (2013.01); C12N 15/743 (2013.01); C12N 15/8258 (2013.01); C12N 15/86 (2013.01); A61K 2039/505 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2319/33 (2013.01); C07K 2319/55 (2013.01)] | 16 Claims |
1. A method of treating cancer in a subject, comprising:
providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain comprises a chlorotoxin peptide and/or a chlorotoxin-like peptide and is capable of binding to a cancer cell;
wherein the composition includes a sequence comprising SEQ ID NO: 9. SEQ ID NO: 10, SEQ ID NO: 11, or SEQ ID NO: 12; and
treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
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