CPC C07D 519/00 (2013.01) [C07D 471/04 (2013.01)] | 11 Claims |
1. A process for preparing a compound of Formula I
or a pharmaceutically acceptable salt thereof, wherein the process comprises the steps of:
a) treating a compound of formula 35
or a salt thereof with a first triflating reagent to form a compound of formula 36
or a salt thereof;
b) treating the compound of formula 36 or a salt thereof with a compound of formula
or a salt thereof, wherein X represents a halogen or a sulfonate and R6 represents a boronic acid or ester with the boron atom as the point of attachment to the pyridine ring of compound 12, in the presence of a third catalyst comprising a metal to form the compound of formula 13 or a salt thereof
c) treating a compound of formula 13 with a compound of formula 14
or a salt thereof, wherein R1 is an amine protecting group, to form the compound of formula 15 or a salt thereof,
d) treating compound 15 with a deprotecting agent to form the compound of formula 16 or a salt thereof
e) treating the compound of formula 16 or a salt thereof with 6-methoxynicotinaldehyde and a reducing agent to form the compound of Formula I or a pharmaceutically acceptable salt thereof.
|