US 11,807,644 B2
Methods and compounds for restoring mutant p53 function
Binh Vu, North Caldwell, NJ (US); Romyr Dominique, East Brunswick, NJ (US); Hongju Li, Edison, NJ (US); Bruce Fahr, East Windsor, NJ (US); and Andrew Good, Wallingford, CT (US)
Assigned to PMV PHARMACEUTICALS, INC., Princeton, NJ (US)
Filed by PMV Pharmaceuticals, Inc., Cranbury, NJ (US)
Filed on May 11, 2021, as Appl. No. 17/317,423.
Claims priority of provisional application 63/023,601, filed on May 12, 2020.
Prior Publication US 2023/0002403 A1, Jan. 5, 2023
Int. Cl. C07D 491/107 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 495/04 (2006.01); C07D 498/18 (2006.01)
CPC C07D 491/107 (2013.01) [C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 495/04 (2013.01); C07D 498/18 (2013.01)] 21 Claims
 
1. A compound of the formula:

OG Complex Work Unit Chemistry
wherein:
A is a substituted or unsubstituted ring;
R1 is alkyl, alkenyl, alkynyl, alkoxy, aryl, heteroaryl, heterocyclyl, or halo, each of which is independently substituted or unsubstituted; or —C(O)R16, —C(O)OR16, —C(O)NR16R17, —OR16, —SR16, —NR16R17, —NR16C(O)R16, —OC(O)R16, —SiR16R17R18, or hydrogen;
each R3 and R4 is independently alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or unsubstituted; or —C(O)R19, —C(O)OR19, —C(O)NR19R20, —SOR19, —S02R19, or hydrogen, or R3 and R4 together with the nitrogen atom to which R3 and R4 are bound form a ring, wherein the ring is substituted or unsubstituted;
each R16, R17, and R18 is independently alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or unsubstituted; or —C(O)R21, —C(O)OR21 —C(O)NR21R22, —OR21, —SR21, —NR21R22, —NR21C(O)R22, —OC(O)R21, hydrogen, or halogen;
each R19 and R20 is independently alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or unsubstituted; or —C(O)R23, —C(O)OR23, —C(O)NR23R24, —OR23, —SR23, —NR23R24, —NR23C(O)R24, —OC(O)R23, hydrogen, or halogen;
each R21 and R22 is independently alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or unsubstituted, or hydrogen; and
each R23 and R24 is independently alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or unsubstituted, or hydrogen,
or a pharmaceutically-acceptable salt thereof.