CPC C07D 207/16 (2013.01) [A61P 7/00 (2018.01); A61P 17/00 (2018.01); A61P 17/10 (2018.01); C07D 207/24 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 409/14 (2013.01)] | 35 Claims |
1. A compound represented by Formula (I), or a pharmaceutically acceptable salt thereof:
wherein, independently for each occurrence:
R1 represents —OH, —ORc, —NH2, —NHRc, —NRcRd, alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, halo, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, —C(O)Rc, —C(O)OH, —C(O)ORc, —OC(O)Rc, —C(O)NH2, —C(O)NHRc, —C(O)NRcRd, —NHC(O)Rc, or —NRcC(O)Rd;
W is —C(O)NH—;
R2 represents optionally substituted aryl or heteroaryl;
V represents optionally substituted aryl or heteroaryl;
Z is absent or represents one or more substituents independently selected from the group consisting of halo, haloalkyl, —NO2, —CN, —C(O)Rc, —C(O)OH, —C(O)ORc, —OC(O)Rc, —C(O)NH2, —C(O)NHRc, —C(O)NRcRd, —NHC(O)Rc, —N(Rc)C(O)Rd, —OS(O)p(Rc), —NHS(O)p(Rc), and —NRcS(O)p(Rc);
X represents —C(NH2)—, —C(NH(Rc))—, —C(NRcRd)—, —C(NHS(O)pRc)—, —C(NHC(O)Rc)—, —C(NHC(O)NH2)—, —C(NHC(O)NHRc)—, —C(NHC(O)NRcRd)—, —C(OH) —C(O(alkyl))—, —C(N3)—, —C(CN)—, —C(NO2)—, —C(S(O)nRa)—, —C[—C(═O)Rc]—, —C[—C(═O)NRcRd]—, —C[—C(═O)SRc]—, —C[—S(O)Rc]—, —C[—S(O)2Rc]—, —C[S(O)(ORc)]—, —C[—S(O)2(ORc)]—, —C[—SO2NRcRd]—, —C(halogen)-, —C(alkyl), —C((cycloalkyl)alkyl), —C(alkenyl)-, —C(alkynyl)-, or —C(aralkyl)-;
R3 represents optionally substituted aryl, heteroaryl, cycloalkyl, or heterocycloalkyl;
R3a is absent or represents one or more substituents independently selected from the group consisting of halo, hydroxy, alkyl, —CF3, —OCF3, alkoxy, aryl, heteroaryl, aryloxy, amino, aminoalkyl, —C(O)NH2, cyano, —NHC(O)alkyl, -SO2alkyl, —SO2NH2, cycloalkyl, —(CH2)rORa, —NO2, —(CH2)rNRaRb, —(CH2)rC(O)Ra, —NRaC(O)Rb, —C(O)NRcRd, —NRaC(O)NRcRd, —C(═NRa)NRcRd, —NHC(═NRa)NRcRd, —NRaRb, —SO2NRcRd, —NRaSO2NRcRd, —NRaSO2alkyl, —NRaSO2Ra, —S(O)pRa, —(CF2)rCF3, —NHCH2Ra, —OCH2Ra, —SCH2Ra, —NH(CH2)2(CH2)rRa, —O(CH2)2(CH2)rRa, and —S(CH2)2(CH2)rRa;
Y represents a bond; or —Y—R4 represents optionally substituted -alkylene-R4, —CH2C(O)—R4, —CH2NH—R4, —CH2N(alkyl)-R4, —CRaRb—R4, —NH—R4, —NHCH2-R4, —NHC(O)—R4, —N(alkyl)-R4, —N(alkyl)CH2-R4, —N((CH2)2OH)—R4, —N((cycloalkyl)alkyl)R4, -heterocyclyl-R4, —OR4, —OCH2-R4, —OC(O)—R4, —OC(O)NRaRb, —SCH2R4, or —SR4;
R4 represents hydrogen, hydroxy, optionally substituted alkyl, cycloalkyl, (heterocycloalkyl)alkyl, (cycloalkyl)alkyl, —CH2OH, —CH(alkyl)OH, —CH(NH2)CH(alkyl)2, aryl, aralkyl, heteroaryl, heteroaralkyl, —CH2S(alkyl), amino, or cyano; or —(CRaRb)r(CRaRb)p— fused to the 4-position of the ring bearing Z to form a 5- to 7-membered heterocyclic ring with optional substituents; or,
when R3 is phenyl, R4 can represent —NRa— fused to the position ortho to X on that phenyl;
each Ra and Rb is independently H, alkyl, alkenyl, alkynyl, aralkyl, (cycloalkyl)alkyl, —C(═O)Rc, —C(═O)ORc, —C(═O)NRcRd, —C(═O)SRc, —S(O)Rc, —S(O)2Rc, —S(O)(ORc), or —SO2NRcRd;
Rc and Rd represent, independently for each occurrence, optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, —C(O)alkyl, or —S(O)p(alkyl); or Rc and Rd can be taken together to form an optionally substituted heterocyclic ring;
r is 0, 1, 2, or 3;
n is an integer from 0 to 6; and
p is 0, 1, or 2.
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