	US 11,807,598 B2
	Process for preparing fatty acid chlorides and N-acyl amino acid salts
Prerak Rajendrakumar Contractor, Singapore (SG); Raju Dayaram Patil, Gujarat (SG); and Jignalkumar Nurpeshkumar Soni, Gujarat (SG)
Assigned to CLARIANT INTERNATIONAL LTD, Muttenz (CH)
Appl. No. 17/290,502
Filed by Clariant International Ltd., Muttenz (CH); and Transpek Industry Limited, Gujarat (IN)
PCT Filed Oct. 30, 2019, PCT No. PCT/EP2019/079715 § 371(c)(1), (2) Date Apr. 30, 2021, PCT Pub. No. WO2020/089326, PCT Pub. Date May 7, 2020.
Claims priority of application No. 201811041255 (IN), filed on Oct. 31, 2018.
Prior Publication US 2021/0380520 A1, Dec. 9, 2021
Int. Cl. C07C 51/60 (2006.01); A61K 8/44 (2006.01)

CPC C07C 51/60 (2013.01) [A61K 8/44 (2013.01); A61K 2800/10 (2013.01); A61K 2800/805 (2013.01)]

26 Claims

1. A process for preparing a fatty acid chloride of formula R—COCl, wherein R is a linear or branched, saturated alkyl group having from 6 to 30 carbon atoms, or a linear or branched, mono- or polyunsaturated alkenyl group having from 6 to 30 carbon atoms,

wherein the process comprises the steps of

i) providing a fatty acid of formula R—COOH, and

ii) reacting the fatty acid of step i) with phosphorous trichloride, thionyl chloride or phosgene, in the presence of a catalyst to form a fatty acid chloride of formula R—COCl, wherein the catalyst is an amine, and wherein the amine is selected from the group consisting of amino acids and amino ethane sulfonic acids.