CPC A61N 1/0448 (2013.01) [A61K 9/0009 (2013.01); A61K 9/0043 (2013.01); A61N 1/0436 (2013.01); A61N 1/0546 (2013.01); A61N 1/306 (2013.01)] | 21 Claims |
1. An apparatus, comprising:
a degradable structure comprising one of a plurality of reservoirs and containing a volume of iontophoretic fluid and including a delivery interface configured to be placed in operative apposition with a tissue surface within a nasal cavity of a subject, the iontophoretic fluid including a therapeutic sub stance;
another one of the plurality of reservoirs containing another volume of the iontophoretic fluid and including another delivery interface configured to be placed in operative apposition with another tissue surface within the nasal cavity of the subject, the one of the plurality of reservoirs being implemented in a first structure form and the another one of the plurality of reservoirs being implemented in a second structure form, wherein
the first structure form is selected from the group consisting of a container, a cup, a flexible bag, a sponge, a foam, a mousse, a hydrogel, a thin film, a membrane, and a mass of fibrous material,
the second structure form is selected from the group consisting of the container, the cup, the flexible bag, the sponge, the foam, the mousse, the hydrogel, the thin film, the membrane, and the mass of fibrous material, and
the second structure form is different from the first structure form;
an electrode device including a proximal portion disposed outside of a nasal cavity and a distal portion including a plurality of electrodes configured to extend into the nasal cavity into engagement with a portion of the degradable structure and the another one of the plurality of reservoirs, the electrode device configured to apply a current to the degradable structure and the another one of the plurality of reservoirs such that an amount of therapeutic substance is delivered to target areas below the tissue surface,
the degradable structure configured to maintain the delivery interface against the tissue surface for at least a first predefined period of time during which current is being applied by the electrode device to the degradable structure, the degradable structure further configured to degrade over a second period of time after being disposed within the nasal cavity.
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