US 11,806,496 B2
Adaptive, closed-loop ultrasound therapy
Kobi Vortman, Haifa (IL); Yoav Levy, Hinanit (IL); Oleg Prus, Haifa (IL); and Shuki Vitek, Haifa (IL)
Assigned to Insightec Ltd., Tirat Carmel (IL)
Appl. No. 16/771,768
Filed by INSIGHTEC, LTD., Tirat Carmel (IL)
PCT Filed Dec. 5, 2018, PCT No. PCT/IB2018/001603
§ 371(c)(1), (2) Date Jun. 11, 2020,
PCT Pub. No. WO2019/116107, PCT Pub. Date Jun. 20, 2019.
Claims priority of provisional application 62/597,071, filed on Dec. 11, 2017.
Claims priority of provisional application 62/597,076, filed on Dec. 11, 2017.
Claims priority of provisional application 62/597,073, filed on Dec. 11, 2017.
Prior Publication US 2021/0170204 A1, Jun. 10, 2021
Int. Cl. A61M 37/00 (2006.01); A61N 7/00 (2006.01); A61N 7/02 (2006.01)
CPC A61M 37/0092 (2013.01) [A61N 7/00 (2013.01); A61N 7/02 (2013.01); A61M 2205/50 (2013.01); A61M 2230/04 (2013.01); A61M 2230/205 (2013.01); A61N 2007/0004 (2013.01); A61N 2007/0039 (2013.01); A61N 2007/0052 (2013.01); A61N 2007/0056 (2013.01); A61N 2007/0073 (2013.01); A61N 2007/0078 (2013.01); A61N 2007/0095 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for focusing an ultrasound transducer comprising:
an ultrasound transducer comprising a plurality of transducer elements;
two or more acoustic-signal detectors for indirectly measuring a focusing property at a target region including an exogenous agent or microbubbles in proximity thereto; and
a controller configured to:
(a) cause the ultrasound transducer to transmit ultrasound waves to the target region;
(b) cause the two or more acoustic-signal detectors to indirectly measure the focusing property by measuring acoustic signals from the exogenous agent or microbubbles from the target region at two or more regions of the transducer elements, wherein the focusing property comprises at least one of an acoustic pressure or a peak acoustic intensity; and
(c) based at least in part on the indirectly measured focusing property from the target region at the two or more regions of the transducer elements, adjust a parameter value associated with the two or more regions of the transducer elements so as to achieve a target treatment power at the target region, wherein the parameter value comprises at least one of a frequency, a phase, a power level, or an amplitude of a signal driving the two or more regions of the transducer elements.