CPC A61K 9/19 (2013.01) [A61K 9/1623 (2013.01); A61K 9/1694 (2013.01); A61K 39/12 (2013.01); A61K 39/295 (2013.01); A61K 45/06 (2013.01); C12N 7/00 (2013.01); A61K 2039/5252 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55572 (2013.01); C12N 2710/20034 (2013.01); C12N 2710/20063 (2013.01); C12N 2710/20071 (2013.01)] | 25 Claims |
1. An essentially dried immunogenic composition comprising:
a single broad-spectrum multi-targeted antigen complex of two or more different pathogens or serotypes, wherein the single complex comprises at least two assembled subunits from the two or more different pathogens or serotypes;
one or more aluminum salt adjuvants;
one or more immunologically-related co-stimulatory agents;
one or more non-reducing disaccharide agents selected from the group consisting of trehalose, sucrose, or a combination thereof;
one or more volatile salts, wherein the one or more volatile salts are selected from the group consisting of one or more of ammonium acetate, ammonium formate, triethylammonium acetate, triethylammonium formate, triethylammonium carbonate, trimethylamine acetate, trimethylamine formate, trimethylamine carbonate, pyridinal acetate and pyridinal formate, or combinations thereof; and
wherein the essentially dried immunogenic composition excludes mannitol.
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