CPC A61K 51/088 (2013.01) [A61K 49/0004 (2013.01); C07K 16/2818 (2013.01)] | 20 Claims |
1. A method of monitoring the progress of an anti-tumor therapy against target-expressing tumors in a subject, the method comprising
(a) administering to the subject an imaging agent that binds specifically to the target molecule at a dose of about 3-10 mCi (100-333 MBq); and
(b) conducting a PET scan of the subject about 30-120 minutes after step (a), wherein steps (a) and (b) are conducted at least 1, 2, 3, 4 or 5 time points, one of which is prior to the initiation of the anti-tumor therapy, and at least one of which during the immunotherapy treatment, or wherein all time points are during the anti-tumor therapy, wherein the imaging agent comprises a protein linked to a radioactive PET tracer by a bifunctional conjugating moiety (BFC) comprising a reactive group that forms a covalent bond with an amine, carboxyl, carbonyl or thiol functional group on the protein, and
wherein the dimension and location of the diseased cells or tissue at each time point is indicative of the progress of the target-expressing tumor.
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