US 11,806,396 B2
Nano-particles that contain synthetic variants of GM3 ganglioside as adjuvants in vaccines
Luis Enrique Fernández Molina, Havana (CU); Belinda Sánchez Ramírez, Havana (CU); Audry Fernández Gómez, Havana (CU); Gretchen Bergado Báez, Havana (CU); Circe Mesa Pardillo, Havana (CU); Lisset Chao García, Sancti Spiritus (CU); Narjara González Suárez, Havana (CU); Dayana Pérez Martínez, Havana (CU); Diana Rosa Hernández Fernández, Havana (CU); Mabel Cruz Rodríguez, Havana (CU); Ángel Alexis Manso Vargas, Havana (CU); Vicente Guillermo Verez Bencomo, Havana (CU); Blanca Idelmis Tolón Murguía, Havana (CU); Miguel Antonio López López, Havana (CU); and Jesús Arturo Junco Barranco, Camagüey (CU)
Assigned to Centro de Inmunología Molecular, Havana (CU)
Appl. No. 16/760,954
Filed by Centro de Inmunología Molecular, Havana (CU)
PCT Filed Oct. 24, 2018, PCT No. PCT/CU2018/050003
§ 371(c)(1), (2) Date May 1, 2020,
PCT Pub. No. WO2019/086056, PCT Pub. Date May 9, 2019.
Claims priority of application No. 2017-0137 (CU), filed on Nov. 6, 2017.
Prior Publication US 2020/0268878 A1, Aug. 27, 2020
Int. Cl. A61K 39/39 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01); A61K 9/51 (2006.01)
CPC A61K 39/39 (2013.01) [A61K 9/5161 (2013.01); A61K 9/5169 (2013.01); A61K 39/001106 (2018.08); A61P 35/00 (2018.01); A61K 2039/55516 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55572 (2013.01)] 18 Claims
OG exemplary drawing
 
1. An adjuvant comprising nanoparticles comprising GM3 ganglioside and hydrophobic proteins of the outer membrane complex of the bacterium Neisseria meningitidis,
wherein the fatty acid in the ceramide of the GM3 ganglioside consists of oleic acid (18:1), and
wherein the GM3 ganglioside and hydrophobic proteins of the outer membrane complex of the bacterium Neisseria meningitides are in association with each other.