US 11,806,323 B2
Topical anesthetics
Pendleton Wickersham, San Antonio, TX (US); Stephen Bendel, Las Cruces, NM (US); Todd Mathis, San Antonio, TX (US); and Christian Warren, Larkspur, CO (US)
Assigned to PTC Innovations, LLC, San Antonio, TX (US)
Filed by PTC Innovations, LLC, San Antonio, TX (US)
Filed on Nov. 30, 2022, as Appl. No. 18/072,642.
Application 18/072,642 is a division of application No. 17/689,827, filed on Mar. 8, 2022, granted, now 11,596,612.
Claims priority of provisional application 63/317,868, filed on Mar. 8, 2022.
Prior Publication US 2023/0285332 A1, Sep. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4453 (2006.01); A61K 31/495 (2006.01); A61P 23/02 (2006.01); A61K 31/167 (2006.01); A61K 45/06 (2006.01); C07C 233/29 (2006.01)
CPC A61K 31/167 (2013.01) [A61K 31/4453 (2013.01); A61K 31/495 (2013.01); A61K 45/06 (2013.01); A61P 23/02 (2018.01); C07C 233/29 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A compound of formula (VI):

OG Complex Work Unit Chemistry
wherein:
R1 is H, Cl, F, —CF3, —OCF3, —OMe, or methyl;
R8 is selected from the group consisting of:
—NH2, —N(H)Alk, —N(Alk)2,

OG Complex Work Unit Chemistry
R7 is H or alkyl;
m is 3 to 6;
p is 1 to 4;
q is 1 to 4;
p+q is 3 to 6; and
each Alk is independently an aliphatic carbon group consisting of 1 to 6 carbon atoms.