US 11,805,784 B2
Use of hydroxyapatite as a carrier of bioactive substances for treating vascular diseases in plants
Massimo Piva, Castel Maggiore (IT); Matteo Coletti, Moscow (RU); Enrico Battiston, Musile di Piave (IT); and Gianluca Manfredini, Castel Maggiore (IT)
Assigned to NDG NATURAL DEVELOPMENT GROUP S.R.L., Castel Maggiore (IT)
Filed by NDG NATURAL DEVELOPMENT GROUP S.R.L., Castel Maggiore (IT)
Filed on May 10, 2021, as Appl. No. 17/315,557.
Application 17/315,557 is a continuation in part of application No. 15/574,419, abandoned, previously published as PCT/IB2016/052863, filed on May 17, 2016.
Claims priority of application No. 102015000015570 (IT), filed on May 18, 2015.
Prior Publication US 2021/0337808 A1, Nov. 4, 2021
Int. Cl. A01N 65/22 (2009.01); A01N 59/20 (2006.01); A01N 25/08 (2006.01); A01N 65/28 (2009.01); A01N 65/24 (2009.01); A01N 65/36 (2009.01)
CPC A01N 65/22 (2013.01) [A01N 25/08 (2013.01); A01N 59/20 (2013.01); A01N 65/24 (2013.01); A01N 65/28 (2013.01); A01N 65/36 (2013.01)] 4 Claims
 
1. A carrier loaded with bioactive substances, wherein the carrier is carbonate substituted hydroxyapatite;
and
the bioactive substances are an ion and a plant extract, wherein said ion is selected from the group consisting of Cu, Zn and a combination thereof,
wherein said bioactive substances are adsorbed on the hydroxyapatite,
wherein in said carbonate substituted hydroxyapatite the copper ion is adsorbed in an amount ranging from 20 to 80 weight % with respect to the weight of said carbonate substituted hydroxyapatite and/or the zinc ion is adsorbed in an amount ranging from 5 to 30 weight % with respect to the weight of said carbonate substituted hydroxyapatite, wherein said plant extract is adsorbed in an amount ranging from 1 to 50 weight % with respect to the weight of said carbonate substituted hydroxyapatite, and
wherein the plant extract consists of:
from 10 to 40 weight % of mint extract;
from 15 to 35 weight % of rosemary extract;
from 5 to 15 weight % of Ocimum basilicum extract;
from 3 to 23 weight % of lemon extract;
from 1 to 10 weight % of garlic extract;
from 3 to 20 weight % of clove extract;
from 3 to 13 weight % of thyme extract; and
from 3 to 10 weight % of cinnamon extract.