US 11,791,144 B2
Optimizing mass spectra signal quality
Bennett S. Kalafut, San Jose, CA (US); Joshua A. Silveira, Gilroy, CA (US); Abhishek Joshi, Urbana, IL (US); and Eloy R. Wouters, San Jose, CA (US)
Assigned to Thermo Finnigan LLC, San Jose, CA (US)
Filed by Thermo Finnigan LLC, San Jose, CA (US)
Filed on Mar. 10, 2021, as Appl. No. 17/197,986.
Prior Publication US 2022/0293405 A1, Sep. 15, 2022
Int. Cl. H01J 49/00 (2006.01); H01J 49/42 (2006.01)
CPC H01J 49/0036 (2013.01) [H01J 49/426 (2013.01)] 33 Claims
OG exemplary drawing
 
1. A system comprising:
one or more processors; and
memory storing executable instructions that, when executed by the one or more processors, cause a computing device to:
receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer; and
control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet, wherein the controlling the automated motion system to adjust the position of the emitter relative to the inlet comprises performing an iterative optimization process configured to optimize a cost function that balances signal quality of the mass spectra and robustness of the mass spectrometer.