US 11,791,060 B2
Elution protocols and dosages for radiopharmaceutical elution system
Etienne Lefort, Kirkland (CA); Riccardo Santopietro, Pierrefonds (CA); Robert William Riddoch, Pierrefonds (CA); and Paul Donnelly, L'lle Bizard (CA)
Assigned to Jubilant Draximage Inc.
Filed by Jubilant Draximage Inc., Kirkland (CA)
Filed on Mar. 27, 2020, as Appl. No. 16/832,436.
Claims priority of provisional application 62/826,711, filed on Mar. 29, 2019.
Prior Publication US 2020/0312474 A1, Oct. 1, 2020
Int. Cl. G21G 1/00 (2006.01); A61M 5/00 (2006.01); A61M 5/14 (2006.01); A61M 5/142 (2006.01)
CPC G21G 1/0005 (2013.01) [A61M 5/007 (2013.01); A61M 5/14 (2013.01); A61M 2005/14208 (2013.01); A61M 2205/3334 (2013.01); A61M 2205/3337 (2013.01); A61M 2205/502 (2013.01); A61M 2205/581 (2013.01); A61M 2205/583 (2013.01); A61M 2210/0693 (2013.01); A61M 2210/08 (2013.01); A61M 2210/1082 (2013.01); A61M 2210/125 (2013.01); G21G 2001/0031 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A radioisotope elution system comprising a radioisotope generator containing a parent radioisotope that decays into a daughter radioisotope, a patient line for infusing a patient with a daughter radioisotope eluate generated by the generator, a pump for pumping an eluant from an eluant reservoir into the generator, and a controller for controlling the pump; wherein the radioisotope elution system is characterized in that:
the controller is configured to calculate a real time amount of daughter radioisotope that is available in the generator from 5 minutes to 10 minutes from the start of an establishment of an equilibrium for decay of the parent radioisotope into the daughter radioisotope;
the controller is configured to provide real time information before the establishment of the equilibrium, said real time information comprising the amount of eluted daughter radioisotope that can be infused to the patient following 5 minutes or 6 minutes from the start of the establishment of the equilibrium for decay of the parent radioisotope into the daughter radioisotope, and,
the controller is configured to calculate a time that remains until the establishment of the equilibrium for decay of the parent radioisotope into the daughter radioisotope and to start a subsequent patient infusion when an available amount of the daughter radioisotope in the generator is sufficient for the patient infusion.