US 11,788,957 B2
Method and system for analyzing a sample desorbed at different temperatures using cavity ring-down spectroscopy, and a method for generating a predictive model
Gisia Beydaghyan, Moncton (CA); Christopher Quentin Purves, Moncton (CA); Stephen Douglas Graham, Bedford (CA); Erik Justin Scheme, Hanwell (CA); and Angkoon Phinyomark, Douglas (CA)
Assigned to Picomole Inc., Moncton (CA)
Filed by Picomole Inc., Moncton (CA)
Filed on Jul. 28, 2021, as Appl. No. 17/443,873.
Application 17/443,873 is a continuation of application No. 16/740,026, filed on Jan. 10, 2020, granted, now 11,105,739.
Claims priority of provisional application 62/828,750, filed on Apr. 3, 2019.
Prior Publication US 2021/0356392 A1, Nov. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/39 (2006.01); G01N 33/497 (2006.01); G01N 1/40 (2006.01); G01J 3/42 (2006.01); G01N 21/3504 (2014.01); G01N 21/552 (2014.01); G01J 3/02 (2006.01); G01N 21/31 (2006.01); G01J 3/10 (2006.01); G06N 20/00 (2019.01); G01N 21/77 (2006.01)
CPC G01N 21/39 (2013.01) [G01J 3/0205 (2013.01); G01J 3/10 (2013.01); G01J 3/42 (2013.01); G01N 1/40 (2013.01); G01N 21/31 (2013.01); G01N 21/3504 (2013.01); G01N 21/552 (2013.01); G01N 33/497 (2013.01); G01J 2003/423 (2013.01); G01N 2021/391 (2013.01); G01N 2021/398 (2013.01); G01N 2021/7789 (2013.01); G01N 2033/4975 (2013.01); G06N 20/00 (2019.01)] 17 Claims
OG exemplary drawing
 
1. A method for analyzing a sample using cavity ring-down spectroscopy, comprising:
desorbing a first part of a breath sample from a thermal desorption tube heated to a first desorption temperature to load the first part of the breath sample into a ring-down cavity;
for each of a first set of wavelengths:
generating, via at least one laser, a laser beam at the wavelength directed into the ring-down cavity;
extinguishing the laser beam entering the ring-down cavity; and
registering light intensity decay data for light exiting the ring-down cavity via a light intensity sensor system;
loading a second part of the sample desorbed from the thermal desorption tube heated to a second desorption temperature;
for each of a second set of wavelengths:
generating, via at least one laser, a laser beam at the wavelength directed into the ring-down cavity;
extinguishing the laser beam entering the ring-down cavity; and
registering light intensity decay data for light exiting the ring-down cavity via a light intensity sensor system; and
determining, via at least one processor, a probability from the light intensity decay data using a predictive model that is at least partially based on the dataset of light intensity decay data for the first set of wavelengths and the second set of wavelengths that a subject from which the breath sample was received has a physiological condition or a degree of a physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed breath samples for which the presence or absence of lung cancer or the degree of lung cancer has been identified.