US 11,788,949 B2
Systems and methods for improved imaging and fluorescence in flow cytometry and other applications
Michael D Ward, Eugene, OR (US); Gregory Kaduchak, Chandler, AZ (US); and Dmitriy Strelkov, Eugene, OR (US)
Assigned to Life Technologies Corporation, Carlsbad, CA (US)
Filed by Life Technologies Corporation, Carlsbad, CA (US)
Filed on Dec. 13, 2021, as Appl. No. 17/548,964.
Claims priority of provisional application 63/125,290, filed on Dec. 14, 2020.
Claims priority of provisional application 63/183,126, filed on May 3, 2021.
Prior Publication US 2022/0187189 A1, Jun. 16, 2022
Int. Cl. G01N 15/14 (2006.01); G01N 15/00 (2006.01)
CPC G01N 15/1436 (2013.01) [G01N 2015/0065 (2013.01); G01N 2015/1438 (2013.01); G01N 2015/1443 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An imaging system, comprising:
a sample region configured to receive a sample;
a laser illumination train configured to provide laser illumination to the sample region to give rise to fluorescence of a sample in the sample region;
an optical illumination train configured to provide imaging illumination to illuminate a sample in the sample region for imaging;
a fluorescence train configured to collect fluorescence evolved in the sample region;
a sample region lens in optical communication with the sample region,
the sample region lens being configured (i) to direct illumination collected from the sample region to the fluorescence train and (ii) to direct illumination from the optical illumination train to the sample region;
an image capture train comprising an imager configured to collect an image of a sample in the sample region illuminated by the imaging illumination.