CPC C12Q 1/6886 (2013.01) [C12Q 1/6841 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01)] | 12 Claims |
2. A system for in situ detection of a control region of human chromosome 17, said system comprising:
a set of two or more single-stranded control probes specific for X distinct monomers of an alpha satellite control region of human chromosome 17, wherein X=2-14, the control probes are each labeled with at least one first label, wherein the control probes can achieve an enumerable signal when hybridized to chromosome 17, each enumerable signal having a generally round shape, wherein a round shape is a shape defined by a simple closed curve fitting within a first region, the first region being an area on and between an inner concentric circle and an outer concentric circle, the inner concentric circle having an inner radius (Rin) and the outer concentric circle having an outer radius (Rout) wherein Rin is ≥ 50% of Rout, and the simple closed curve having a radius Rsimple, wherein Rin≤ Rsimple≤ Rout, and wherein the simple closed curve is a connected curve that does not cross itself and ends at the same point where it begins.
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