US 11,788,073 B2
Polymerase variants and uses thereof
Aruna Ayer, Santa Clara, CA (US); Cleoma Arnold, San Jose, CA (US); Charles Wayan Schwab, San Ramon, CA (US); Eileen Thai, San Jose, CA (US); Ilya Lederman, San Francisco, CA (US); Colin Alexander McGaw, Santa Clara, CA (US); and Tyler O'Brien Shultz, Santa Clara, CA (US)
Assigned to Roche Sequencing Solutions, Inc., Pleasanton, CA (US)
Filed by Roche Sequencing Solutions, Inc., Pleasanton, CA (US)
Filed on Mar. 5, 2021, as Appl. No. 17/249,605.
Application 17/249,605 is a continuation of application No. 16/694,985, filed on Nov. 25, 2019, granted, now 10,968,438.
Application 16/694,985 is a continuation of application No. 15/151,364, filed on May 10, 2016, granted, now 10,526,588, issued on Jan. 7, 2020.
Application 15/151,364 is a continuation in part of application No. 15/012,317, filed on Feb. 1, 2016, granted, now 10,308,918, issued on Jun. 4, 2019.
Claims priority of provisional application 62/202,895, filed on Aug. 9, 2015.
Claims priority of provisional application 62/161,571, filed on May 14, 2015.
Prior Publication US 2021/0189355 A1, Jun. 24, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 9/12 (2006.01)
CPC C12N 9/1241 (2013.01) [C12N 9/1252 (2013.01); C12Y 207/07 (2013.01); C12Y 207/07007 (2013.01)] 5 Claims
 
1. A modified deoxyribonucleic acid (DNA) polymerase comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO: 2, which amino acid sequence includes an amino acid substitution selected from the group consisting of Y225M, H227E/F/Y, S360E/Y, L361F, I363A/R/M/W, Y367F, H527Y/T/M, M531G, N535R/W/Q, P542G, N545Q/W, L549K, N552T, G553E/Q/K/R/M, G603A/L, C623F, D624K, I628L/M, Y629K, T647Y, I648L, I652A/L/E/K/M, K655Q/M/A, and D657E.