	US 11,788,058 B2
	Protein-modified PLGA microsphere and tissue-engineered nerve constructed therewith
Xin Tang, Jiangsu (CN); Cheng Sun, Jiangsu (CN); Xiaosong Gu, Jiangsu (CN); Youlang Zhou, Jiangsu (CN); and Chunkang Tang, Jiangsu (CN)
Assigned to NANTONG UNIVERSITY, Jiangsu (CN)
Appl. No. 17/596,647
Filed by NANTONG UNIVERSITY, Jiangsu (CN)
PCT Filed Jun. 19, 2020, PCT No. PCT/CN2020/097111 § 371(c)(1), (2) Date Dec. 15, 2021, PCT Pub. No. WO2021/227199, PCT Pub. Date Nov. 18, 2021.
Claims priority of application No. 202010407176.4 (CN), filed on May 14, 2020.
Prior Publication US 2022/0213437 A1, Jul. 7, 2022
Int. Cl. C12N 5/04 (2006.01); C12N 5/0793 (2010.01); A61L 27/26 (2006.01); B82Y 5/00 (2011.01); C07K 14/78 (2006.01)

CPC C12N 5/0619 (2013.01) [A61L 27/26 (2013.01); B82Y 5/00 (2013.01); C07K 14/78 (2013.01); A61L 2400/12 (2013.01); A61L 2430/32 (2013.01); C12N 2533/00 (2013.01)]

7 Claims

1. A protein-modified polylactic-co-glycolic acid (PLGA) microsphere, comprising PLGA cross-linked with laminin through a cross-linking agent, wherein the microsphere is loaded with one or more active substances selected from Gastrodia extract and fat-soluble extract of Brucea javanica L. Merr.