US 11,787,903 B2
Highly strong and tough photo-crosslinked hydrogel material and its preparation and application
Yu Sun, Guangdong (CN)
Assigned to ZHONGSHAN GUANGHE MEDICAL TECHNOLOGY CO., LTD, Guangdong (CN)
Filed by ZHONGSHAN GUANGHE MEDICAL TECHNOLOGY CO., LTD., Guangdong (CN)
Filed on Nov. 24, 2022, as Appl. No. 17/993,884.
Application 17/993,884 is a continuation of application No. PCT/CN2020/106113, filed on Jul. 31, 2020.
Claims priority of application No. 202010481125.6 (CN), filed on May 31, 2020.
Prior Publication US 2023/0130864 A1, Apr. 27, 2023
Int. Cl. C08F 2/46 (2006.01); C08F 2/50 (2006.01); C08G 61/04 (2006.01); C08G 65/333 (2006.01); C08F 283/02 (2006.01); C08J 3/075 (2006.01)
CPC C08G 65/33389 (2013.01) [C08F 283/02 (2013.01); C08J 3/075 (2013.01); C08J 2367/02 (2013.01)] 14 Claims
 
1. A highly strong and tough photo-crosslinked hydrogel material, wherein the highly strong and tough photo-crosslinked hydrogel material is prepared from the following three components in a biocompatible medium:
Component A: o-nitrobenzyl phototrigger modified photosensitive polymer derivative;
Component B: double bond groups modified polymer derivative;
Component C: photoinitiator,
the o-nitrobenzyl phototrigger modified photosensitive polymer derivative is selected from the following component A-1 to A-30:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
the double bond groups modified polymer derivative having a structure shown in Formula III:

OG Complex Work Unit Chemistry
where in the Formula III,
R1′ and R2′ are selected from hydrogen;
R3′ is selected from hydrogen or methyl;
R4′ is selected from an alkyl group, an ether group, an ester group, or an amide group;
n≥2;
P1′ is hydrophilic natural macromolecules or hydrophilic synthetic polymers;
wherein the concentration of the o-nitrobenzyl phototrigger modified photosensitive polymer derivative is 1% wt-40% wt, the concentration of the double bond groups modified polymer derivative is 0.05% wt-10% wt, the concentration of the photoinitiator is 0.1% wt-3% wt, and the rest is the biocompatible medium.