CPC C07K 16/30 (2013.01) [C07K 16/2887 (2013.01); A61K 2039/505 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01)] | 20 Claims |
1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding an antibody which comprises an antigen binding region and a variant Fc region, wherein said variant Fc region is a variant of a human IgG Fc region, and said variant Fc region comprises the following amino acid modifications relative to a wild-type Fc region: F243L, R292P and Y300L, wherein the positions are numbered according to the EU index as in Kabat.
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