CPC C07K 16/2881 (2013.01) [A61P 25/28 (2018.01); C07K 16/18 (2013.01); C07K 16/468 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/52 (2013.01); C07K 2317/522 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/64 (2013.01)] | 5 Claims |
1. A bispecific antibody specifically binding to human A-beta protein and human transferrin receptor, comprising:
a first light chain of SEQ ID NO: 01 or that has a sequence identity to SEQ ID NO: 01 of at least 90%;
a first heavy chain of SEQ ID NO: 02 or that has a sequence identity to SEQ ID NO: 02 of at least 90%;
a second light chain of SEQ ID NO: 03 or that has a sequence identity to SEQ ID NO: 03 of at least 90%; and
a second heavy chain of SEQ ID NO: 10 or that has a sequence identity to SEQ ID NO: 10 of at least 90%,
wherein substitutions, insertions, or deletions occur in regions outside hypervariable regions.
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