US 11,787,868 B2
Bispecific anti-human A-beta/human transferrin receptor antibodies and methods of use
Harald Duerr, Starnberg (DE); Sebastian Fenn, Achmuehle/Eurasburg (DE); Ulrich Goepfert, Penzberg (DE); Sabine Imhof-Jung, Planegg (DE); Christian Klein, Bonstetten (CH); Laurent Lariviere, Munich (DE); Michael Molhoj, Munich (DE); Joerg Thomas Regula, Munich (DE); Petra Rueger, Penzberg (DE); and Wolfgang Schaefer, Mannheim (DE)
Filed by HOFFMANN-LA ROCHE INC., Little Falls, NJ (US)
Filed on Dec. 22, 2020, as Appl. No. 17/130,477.
Application 17/130,477 is a division of application No. 15/941,655, filed on Mar. 30, 2018, granted, now 10,941,205.
Application 15/941,655 is a continuation of application No. PCT/EP2016/073411, filed on Sep. 30, 2016.
Claims priority of application No. 15188064 (EP), filed on Oct. 2, 2015.
Prior Publication US 2021/0301030 A1, Sep. 30, 2021
Prior Publication US 2022/0144963 A9, May 12, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/28 (2006.01); C07K 16/18 (2006.01); C07K 16/46 (2006.01); A61P 25/28 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2881 (2013.01) [A61P 25/28 (2018.01); C07K 16/18 (2013.01); C07K 16/468 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/52 (2013.01); C07K 2317/522 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/64 (2013.01)] 5 Claims
 
1. A bispecific antibody specifically binding to human A-beta protein and human transferrin receptor, comprising:
a first light chain of SEQ ID NO: 01 or that has a sequence identity to SEQ ID NO: 01 of at least 90%;
a first heavy chain of SEQ ID NO: 02 or that has a sequence identity to SEQ ID NO: 02 of at least 90%;
a second light chain of SEQ ID NO: 03 or that has a sequence identity to SEQ ID NO: 03 of at least 90%; and
a second heavy chain of SEQ ID NO: 10 or that has a sequence identity to SEQ ID NO: 10 of at least 90%,
wherein substitutions, insertions, or deletions occur in regions outside hypervariable regions.