CPC C07K 14/4748 (2013.01) [A61K 38/1793 (2013.01); A61K 39/0011 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 14/47 (2013.01); C07K 14/705 (2013.01); G01N 33/505 (2013.01); G01N 33/5091 (2013.01); G01N 33/56966 (2013.01); G01N 33/56972 (2013.01); A61K 2039/55566 (2013.01); G01N 2333/5409 (2013.01); G01N 2333/57 (2013.01)] | 22 Claims |
1. An isolated peptide that consists of 9-35 amino acid residues, wherein said isolated peptide comprises the peptide of SLLGLKDQV (SEQ ID NO: 2, residues 961-969), GLTRTSVTV (SEQ ID NO: 2, residues 391-399), KLNVEERSV (SEQ ID NO: 2, residues 162-170) or MQNVIMNDMP (SEQ ID NO: 2, residues 55-63),
where said peptide of SLLGLKDQV (SEQ ID NO: 2, residues 961-969), GLTRTSVTV (SEQ ID NO: 2, residues 391-399), KLNVEERSV (SEQ ID NO: 2, residues 162-170) or MQNIMNDMP (SEQ ID NO: 2, residues 55-63):
(i) has up to one conservative amino acid substitution within the conservative substitution groups (a) S and T, (b) L, I and V, and (c) E and D; and
(ii) retains the ability to stimulate a T-cell immune response to EphA2 as determined by ELISPOT assay.
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